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foxo1 inhibitor as1708727  (Merck & Co)

 
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    Merck & Co foxo1 inhibitor as1708727
    (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for <t>FoxO1</t> (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor <t>(AS1708727,</t> iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
    Foxo1 Inhibitor As1708727, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/foxo1 inhibitor as1708727/product/Merck & Co
    Average 90 stars, based on 1 article reviews
    foxo1 inhibitor as1708727 - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "The E3 ubiquitin ligase MARCH3 controls the endothelial barrier"

    Article Title: The E3 ubiquitin ligase MARCH3 controls the endothelial barrier

    Journal: Febs Letters

    doi: 10.1002/1873-3468.12417

    (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
    Figure Legend Snippet: (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.

    Techniques Used: Transfection, Western Blot, Staining, Confocal Microscopy, Reverse Transcription Polymerase Chain Reaction, Permeability



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    foxo1 inhibitor as1708727  (Merck & Co)
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    Merck & Co foxo1 inhibitor as1708727
    (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for <t>FoxO1</t> (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor <t>(AS1708727,</t> iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
    Foxo1 Inhibitor As1708727, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/foxo1 inhibitor as1708727/product/Merck & Co
    Average 90 stars, based on 1 article reviews
    foxo1 inhibitor as1708727 - by Bioz Stars, 2026-02
    90/100 stars
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    foxo1 inhibitor as1708727  (Astellas)
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    Astellas foxo1 inhibitor as1708727
    (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for <t>FoxO1</t> (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor <t>(AS1708727,</t> iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
    Foxo1 Inhibitor As1708727, supplied by Astellas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/foxo1 inhibitor as1708727/product/Astellas
    Average 90 stars, based on 1 article reviews
    foxo1 inhibitor as1708727 - by Bioz Stars, 2026-02
    90/100 stars
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    Image Search Results


    (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.

    Journal: Febs Letters

    Article Title: The E3 ubiquitin ligase MARCH3 controls the endothelial barrier

    doi: 10.1002/1873-3468.12417

    Figure Lengend Snippet: (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.

    Article Snippet: Reagents and Antibodies FoxO1 inhibitor AS1708727 was from Merck and used at 100 nM.

    Techniques: Transfection, Western Blot, Staining, Confocal Microscopy, Reverse Transcription Polymerase Chain Reaction, Permeability